Week 5 of the 2025 NFL season (October 2-6) featured significant player injuries affecting fantasy rosters across all positions. Most featured players were injured in earlier weeks but remained unavailable through Week 5, with one critical injury occurring during Week 5 play itself. This guide provides verified player statuses, injury timelines, and recovery information cross-referenced against official NFL sources and credible sports journalism.[1][2][3][4][5][6][7]
Quarterbacks and Minnesota Vikings Status
J.J. McCarthy suffered a high ankle sprain on September 14 during Week 2 against Chicago. He remained unavailable through Week 7, missing six consecutive games. Carson Wentz started Week 5 in London on October 5 at Tottenham Hotspur Stadium against Cleveland but sustained a dislocated shoulder, fractured socket, and torn labrum during that game.
Despite the injury severity, Wentz continued playing through Weeks 6 and 7 before undergoing season-ending surgery on October 28. McCarthy returned with full practice participation October 29, cleared for Week 9.[8][9][10][11][12][13][14][15][16][17]
Lamar Jackson was unavailable for Week 5 due to hamstring injury sustained September 29 during Week 4 against Kansas City. Cooper Rush and Tyler Huntley served as backup options. Jackson returned Week 9 with full clearance October 30.[18][19][20][21]
Wide Receivers and Extended Absences
- CeeDee Lamb:
suffered a high ankle sprain September 21 during Week 3 against Chicago, not Week 5. George Pickens and Jalen Tolbert assumed primary receiving roles. Lamb returned Week 8 and participated fully Week 9 against Denver.[22][23][24][25]
- Tyreek Hill:
sustained a knee dislocation with multiple ligament tears September 29 during Week 3. He is sidelined for the entire 2025 season with projected 2026 return. His future participation remains undecided as of October 30.[26][27][28][29][30]
- Malik Nabers:
tore his ACL and partial meniscus September 28 during Week 4. He underwent ACL reconstruction and meniscus repair October 28 performed by Dr. Daniel Cooper. Nabers is ruled out for the entire 2025 season.[31][32][33][34][35]
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Tight Ends and Running Backs Impact
| Player | Team | Injury | Week 5 Status | Current Status |
|---|---|---|---|---|
| Brock Bowers | LV | PCL/bone bruise | Rest | Returned Week 9 |
| Will Dissly | LAC | Knee | Inactive | Lost role Week 8 |
Bowers suffered PCL injury and bone bruise Week 1 but played Weeks 2-4. Week 5 strategic rest allowed healing before bye. He returned Week 9 fully recovered.[36][37][38]
Running back absences in Week 5 created backup opportunities: Trey Benson (knee, Arizona), Chuba Hubbard (calf, Carolina), Tyler Goodson (groin, Indianapolis), Braelon Allen (knee, Jets), Bucky Irving (foot, Tampa Bay), and Miles Sanders (knee, Dallas).[39][40][41]



